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Five products of the dynorphin gene--alpha-neo-endorphin, beta-neo-endorphin, dynorphin A, dynorphin A-(1-8), and dynorphin B--were measured in various regions of rat brain and in rat spinal cord and pituitary. Specific antisera were used, supplemented by gel permeation analysis and high performance liquid chromatography, confirming the presence of dynorphin-32, dynorphin A, and dynorphin B in rat brain. In whole brain, alpha-neo-endorphin, dynorphin A-(1-8), and dynorphin B are present in much greater amounts than beta-neo-endorphin or dynorphin A. Although a general parallelism was found in the distribution of the five peptides, there were also noteworthy exceptions, suggesting that differential processing may occur.
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
December 1982,
Biochemical and biophysical research communications,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
September 1981,
Biochemical and biophysical research communications,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
February 1983,
Proceedings of the National Academy of Sciences of the United States of America,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
May 1982,
Proceedings of the National Academy of Sciences of the United States of America,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
March 1982,
The Biochemical journal,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
January 1981,
Peptides,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
May 1984,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
November 1982,
Life sciences,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
July 1982,
Biochemical and biophysical research communications,
R I Cone, and
E Weber, and
J D Barchas, and
A Goldstein
June 1980,
Neuroscience letters,
