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In an attempt to dissociate the cardiovascular adaptations to high blood pressure from those of ageing, 30 patients with established essential hypertension aged over 65 years were matched for mean arterial pressure, race, sex, height, and weight with 30 patients younger than 42 years. Cardiac output, heart rate, stroke volume, intravascular volume, renal blood flow, and plasma renin activity were significantly lower in the elderly, whereas total peripheral (and renal vascular) resistance, left ventricular posterior wall and septal thicknesses, and left ventricular mass were higher. Intravascular volume correlated inversely with total peripheral resistance in both groups and in all patients. Pathophysiological findings of essential hypertension in the elderly are characterised by a hypertrophied heart of the concentric type with a low cardiac output resulting from a smaller stroke volume and a slower heart rate. Renal blood flow is disproportionally reduced and total peripheral and renal vascular resistance elevated.
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
June 1977,
Clinical science and molecular medicine,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
January 1981,
Archives of internal medicine,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
May 1976,
Clinical science and molecular medicine,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
October 1982,
Acta endocrinologica,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
April 1977,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
January 1979,
Medicina,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
November 1973,
Nihon Jinzo Gakkai shi,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
September 1979,
Srpski arhiv za celokupno lekarstvo,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
April 1979,
Klinische Wochenschrift,
F H Messerli, and
K Sundgaard-Riise, and
H O Ventura, and
F G Dunn, and
L B Glade, and
E D Frohlich
December 1987,
Journal of hypertension,
