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Two analogs of somatostatin (Ala2,D-Trp8,D-Cys14-Somatostatin and L-5F-Trp8-Somatostatin) infused into acromegalics at the rate of 4.5 micrograms/min suppressed arginine-stimulated growth hormone release more strongly than 6 micrograms/min somatostatin (110 +/- 11% and 129 +/- 14%, respectively). Under the same conditions the two somatostatin analogs induced a much smaller inhibition of insulin (33 +/- 13% and 44 +/- 18%) and glucagon (28 +/- 10% and 45 +/- 17%, respectively) release than somatostatin did. Somatostatin analogs with dissociated actions could be promising for the treatment of diseases such as acromegaly, diabetes mellitus and some ectopic hormone syndromes.
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
August 1987,
Life sciences,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
January 1977,
Biochemical and biophysical research communications,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
April 1974,
Lancet (London, England),
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
February 1976,
Endocrinology,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
October 1975,
FEBS letters,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
December 1977,
Acta endocrinologica,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
August 2000,
The Journal of clinical endocrinology and metabolism,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
January 1980,
Journal of endocrinological investigation,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
September 1978,
Metabolism: clinical and experimental,
B L Wajchenberg, and
F P Cesar, and
C E Leme, and
V C Borghi, and
V C Souza, and
I T Souza, and
D G Neto, and
O A Germek, and
D H Coy, and
A M Comaru-Schally
April 1976,
Acta endocrinologica,
