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The metabolism of beta-phenethylamine (PEA) has been investigated in intestinal, liver and lung homogenates from the rat. Metabolic activity was ranked liver much greater than lung much greater than duodenum greater than jejunum greater than ileum greater than colon. Absorption and metabolism of PEA was also studied using in-situ intestinal loops from rats. Absorption of PEA appeared to be a passively mediated process with metabolism occurring in jejunum, ileum and colon. When isolated loops of jejunum were used, phenylacetic acid was the only metabolite formed. Presystemic elimination of PEA in anaesthetized rats, was largely attributable to the intestine and lung with a relatively small hepatic contribution.
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