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Cholesterogenesis pathway during pre- and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3-hydroxy-3-methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 1(14)C-acetate incorporation into cholesterol and HMGCoA reductase activity were present at 16 days of fetal development in newborn and suckling rats, whereas both parameters increased rapidly before birth. The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short-term regulatory mechanisms.
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
November 1981,
Biochimica et biophysica acta,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
May 2010,
Naunyn-Schmiedeberg's archives of pharmacology,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
April 1997,
Cell and tissue research,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
March 1996,
Neuroscience letters,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
August 1979,
European journal of cell biology,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
January 1977,
Cell and tissue research,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
September 1990,
The Journal of cell biology,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
May 1973,
Histochemie. Histochemistry. Histochimie,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
May 1968,
The Journal of cell biology,
S Leoni, and
S Spagnuolo, and
L Conti-Devirgiliis, and
L Dini, and
M T Mangiantini, and
A Trentalance
March 1995,
Biochemical pharmacology,
