-transparent.png){kind=logo}
As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysectomized rats. Somatostatin significantly antagonized morphine-induced antinociception in intact, but not in hypophysectomized, animals. TRH, on the other hand, had no effect on antinociceptive response to morphine in either intact or hypophysectomized animals. Neither hormone altered hyperthermic response to morphine but TRH antagonized the hypothermic response. Similarly, TRH antagonized the cataleptic actions of morphine whereas somatostatin had no effect. These results indicate that somatostatin and TRH can attenuate certain actions of morphine in vivo and suggest that specific opiate actions may be modulated by specific hypothalamic hormones.
B G Kasson, and
R George
January 1979,
Annual review of physiology,
B G Kasson, and
R George
March 1975,
Hormones and behavior,
B G Kasson, and
R George
January 1977,
Endocrinologie,
B G Kasson, and
R George
February 2005,
Current opinion in neurobiology,
B G Kasson, and
R George
August 1980,
Brain research,
B G Kasson, and
R George
January 1973,
Casopis lekaru ceskych,
B G Kasson, and
R George
November 1963,
Fukuoka igaku zasshi = Hukuoka acta medica,
B G Kasson, and
R George
December 1972,
Archives of internal medicine,
B G Kasson, and
R George
April 1979,
Ugeskrift for laeger,
B G Kasson, and
R George
September 1996,
The American journal of physiology,
