Biomaterial Database

[Cell culture as an experimental system for studying aging processes]. 1983

M Steinhardt

The investigation of cellular aging has mainly been limited by experimental and descriptive work on two separate cell culture systems. On one hand studies were performed on in vitro aging, comparing fibroblasts in early and late passage. On the other hand, fibroblasts derived from donors of different age were compared (in vivo aging). Recently, results have been achieved, stating that some of the investigated parameters change similarly in both systems. Therefore it is of great importance to find criteria for cellular aging, not only to precise the results in both cell culture systems, but also to be able to draw conclusions concerning aging of the organism in vivo.

UI	MeSH Term	Description	Entries
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D005347	Fibroblasts	Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.	Fibroblast
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In