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Hemodynamic variables were measured in 34 patients with isolated systolic hypertension before and after acute administration of propranolol. The patients were separated into two groups, those younger than and those older than 45 years of age, respectively. After drug administration, systolic pressure decreased significantly (P less than 0.001) in younger subjects with a concomitant increase in rapid ejection time (P less than 0.001). In the older patients, cardiac and peripheral factors determining systolic pressure were each altered after beta-adrenergic blockade. The most striking result was the reduction in systemic arterial compliance (P less than 0.01) probably due to unmasked alpha-adrenergic vasoconstriction. This arterial effect explains the lack of systolic pressure reduction despite a decrease in cardiac performance.
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
February 1970,
The American journal of the medical sciences,
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
October 1976,
The Journal of the Association of Physicians of India,
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
March 1977,
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J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
October 1988,
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J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
May 1972,
Lancet (London, England),
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
March 1968,
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J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
October 1976,
The Journal of the Association of Physicians of India,
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
January 1974,
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J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
May 2001,
The American journal of medicine,
J Levenson, and
A Simon, and
B Maarek, and
J Totomoukouo, and
R Gitelman, and
J Bouthier, and
M Safar
January 1979,
British heart journal,
