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To investigate the value of maintenance chemotherapy after early consolidation treatment, an attempt was made to induce remission in 162 previously untreated patients, age-range 7-65 years (median 43). The 74 patients who were still in remission after early consolidation treatment (given for 3-5 months) were assigned to either maintenance chemotherapy every 8 weeks for 2 years or to observation only. After a median observation period of 44 months there was no difference between the groups in duration of remission or survival. Surprisingly, patients above 40 survived longer after early consolidation (median 4 years) than did patients aged 40 and below (median 1.6 years, p = 0.0002).
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A Gratwohl, and
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F Cavalli
October 1986,
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Lancet (London, England),
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V von Fliedner, and
F Cavalli
September 2003,
Best practice & research. Clinical haematology,
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V von Fliedner, and
F Cavalli
May 1981,
British medical journal (Clinical research ed.),
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A Gratwohl, and
P Imbach, and
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V von Fliedner, and
F Cavalli
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British medical journal (Clinical research ed.),
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Ophthalmic research,
