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A total 31 psychoactive drugs were offered to groups of naive rats for IV self-administration and an injection rate greater than that for rats offered only saline indicated reinforcement. Two protocols were used: in the first, rats were offered drug at a selected dose for 5 days, then the dose was reduced by 1 log unit (to 0.1 the original dose) for an additional 4 days; in the second, rats were offered saline for 3 days as a "prescreen' to eliminate rats with high or low operant-injection rates. Drug was offered to acceptable rats for 5 days, then the dose was reduced 0.5 log unit (to 0.32 the original dose) for 5 more days. A scoring system, based upon the injection rates during the last 3 days of each period, describes the reinforcing action. Scores were dose-related. Tests on both protocols gave similar results. Data from monkey studies have been reported for 27 of the drugs tested. Of these drugs, 18 were reinforcers and six were nonreinforcers in both species, nalorphine and ethylketazocine were reinforcers only in rats, and ethanol was a reinforcer only in monkeys.
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
October 2018,
Psychopharmacology,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
November 2016,
Drug and alcohol dependence,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
December 1991,
British journal of addiction,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
March 2014,
Pharmacology, biochemistry, and behavior,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
January 1979,
Pharmacology & therapeutics. Part B: General & systematic pharmacology,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
January 2011,
Neuroscience and biobehavioral reviews,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
February 1988,
Agents and actions,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
January 2021,
Emerging trends in drugs, addictions, and health,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
December 2000,
Psychopharmacology,
R J Collins, and
J R Weeks, and
M M Cooper, and
P I Good, and
R R Russell
December 2010,
Physiology & behavior,
