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I.v. administration of somatostatin (1.5 micrograms/kg/g) reduced the gastric secretion induced by pentagastrin and histamine. Microapplication of somatostatin to globus pallidus (10 micrograms in 3 ml) increased the acid secretion in the dog stomach. The serum gastrin level was decreased both in the i.v. administration of somatostatin and in its cerebral application.
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