-transparent.png){kind=logo}
Immunological reconstitution by transplantation of HLA-haploidentical, paternal bone marrow was attempted in four infants with severe combined immunodeficiency who lacked HLA-identical donors. To prevent graft-versus-host disease, T lymphocytes were removed from the grafts by agglutination with soybean agglutinin and rosette formation with sheep red blood cells. None of the patients received conditioning treatment before transplantation. Normal, donor-derived cellular immune functions developed in all four patients within several months of transplantation. Threatening complications of graft-versus-host reactions were not seen. All four patients remain in excellent health 12-15 months after discharge home, with persisting normal T-cell functions.
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
November 1991,
Bone marrow transplantation,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
January 2000,
Archivum immunologiae et therapiae experimentalis,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
November 1985,
Journal of clinical immunology,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
October 1982,
Proceedings of the National Academy of Sciences of the United States of America,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
May 2020,
Singapore medical journal,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
October 1993,
Seminars in hematology,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
September 1987,
Clinical immunology and immunopathology,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
April 1996,
Bone marrow transplantation,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
June 2005,
European journal of haematology,
W Friedrich, and
S F Goldmann, and
U Vetter, and
T M Fliedner, and
B Heymer, and
H H Peter, and
Y Reisner, and
E Kleihauer
March 1990,
Journal of clinical immunology,
