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Functional tolerance was demonstrated to the antihypertensive effect of chlorisondamine Cl (Ecolid), a noncompetitive autonomic ganglion blocking agent, when administered chronically in increasing doses to spontaneously hypertensive rats (SHR), and normotensive Wistar-Kyoto (WKY) rats. Concomitant administration of atropine SO4 restored the hypotensive response to chlorisondamine without increasing its serum concentration. Atropine had no effect on the blood pressure of chlorisondamine-naive animals. No qualitative differences in therapeutic response were observed between the SHR and WKY rats. The results support the hypothesis that tolerance to the antihypertensive action of ganglionic blocking agents may be mediated by an activation of an alternate compensatory sympathetic ganglionic muscarinic pathway. It is speculated that this secondary pathway does not contribute to the hypertension in the SHR model.
R W Gardier, and
J A Peters
January 1965,
Therapeutische Umschau. Revue therapeutique,
R W Gardier, and
J A Peters
January 1975,
Perspectives in biology and medicine,
R W Gardier, and
J A Peters
April 1950,
The Journal of pharmacology and experimental therapeutics,
R W Gardier, and
J A Peters
October 1963,
[Sogo rinsho] Clinic all-round,
R W Gardier, and
J A Peters
January 1955,
Il Farmaco; edizione scientifica,
R W Gardier, and
J A Peters
January 1960,
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques,
R W Gardier, and
J A Peters
January 1956,
Actualites pharmacologiques,
R W Gardier, and
J A Peters
October 1962,
The American journal of physiology,
