BIOMAT Database Logo BIOMAT Database Logo

[Benzodiazepines. Factors altering pharmacokinetic parameters and drug interactions]. 1983

E Singlas

Drug level at receptor site dictates the intensity of the pharmacological response. The level which is achieved depends upon several factors such as gastrointestinal absorption, protein binding, distribution, biotransformations and excretion. Modification of anyone of these processes can influence drug level at the site of action and thus the therapeutic effect of the drug. Physiological and pathological states or drug interactions can influence pharmacokinetics of benzodiazepines and thus modification of dosage regimen may be necessary. The influence of aging, liver disease, drug interactions such as alcohol, antidepressants... is of importance. Consequences of these modifications are discussed.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E Singlas
Clinically significant pharmacokinetic drug interactions with benzodiazepines.
October 1999, Journal of clinical pharmacy and therapeutics,
E Singlas
[Importance of pharmacokinetic and pharmacodynamic parameters in drug interactions].
May 2003, Revista espanola de anestesiologia y reanimacion,
E Singlas
Pharmacokinetic Drug-Drug Interactions and Herb-Drug Interactions.
April 2021, Pharmaceutics,
E Singlas
Prediction of Drug-Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation.
September 2019, Drugs in R&D,
E Singlas
Pharmacokinetic drug interactions.
December 1969, Lancet (London, England),
E Singlas
[Pharmacokinetic drug interactions].
March 1978, Pharmazie in unserer Zeit,
E Singlas
Pharmacokinetic drug interactions.
January 1986, Journal of clinical pharmacology,
E Singlas
Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions.
March 2009, Xenobiotica; the fate of foreign compounds in biological systems,
E Singlas
Overview: pharmacokinetic drug-drug interactions.
January 1997, Advances in pharmacology (San Diego, Calif.),
E Singlas
Opioid pharmacokinetic drug-drug interactions.
September 2011, The American journal of managed care,
Copied contents to your clipboard!