Biomaterial Database

Thyroid-stimulating antibody in Graves' disease. 1984

T F Davies

UI	MeSH Term	Description	Entries
D008297	Male		Males
D005260	Female		Females
D006111	Graves Disease	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).	Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000906	Antibodies	Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D001323	Autoantibodies	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.	Autoantibody
D013961	Thyroid Gland	A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.	Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D018828	Immunoglobulins, Thyroid-Stimulating	Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.	Antibodies, Thyroid-Stimulating,Ig Thyroid Stimulating,Thyroid-Stimulating Antibodies,Thyroid-Stimulating Autoantibodies,Thyroid-Stimulating Autoantibody,Thyroid-Stimulating Immunoglobulins,Immunoglobulin, Thyroid-Stimulating,Thyroid Stimulating Antibody,Thyroid-Stimulating Immunoglobulin,Antibody, Thyroid Stimulating,Autoantibody, Thyroid-Stimulating,Immunoglobulin, Thyroid Stimulating,Stimulating Antibody, Thyroid,Thyroid Stimulating Antibodies,Thyroid Stimulating Autoantibodies,Thyroid Stimulating Autoantibody,Thyroid Stimulating Immunoglobulin,Thyroid Stimulating Immunoglobulins,Thyroid Stimulating, Ig