-transparent.png){kind=logo}
The effect of the substituted benzimidazole, omeprazole, a potent inhibitor of gastric acid secretion, on the hepatic elimination of antipyrine was studied in the rat isolated perfused liver. Bolus dosage (10 mg in 100 ml perfusate) and infusions (1 microgram ml-1 perfusate concentrations) of omeprazole in its solvent, polyethylene glycol-400 (PEG-400), reduced antipyrine clearance by approximately one third (P less than 0.05). PEG-400 alone caused a 15% decrease in antipyrine clearance (P greater than 0.10), indicating that the effect seen with omeprazole was at least partly due to the vehicle of dissolution. A significant but mild choleresis was noted in all preparations (P less than 0.01) exposed to PEG-400. We conclude that the effect of omeprazole on hepatic drug elimination in patients warrants further study.
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1993,
Cancer chemotherapy and pharmacology,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1989,
Virchows Archiv. A, Pathological anatomy and histopathology,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
November 1989,
Gastroenterology,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1996,
Journal of pharmaceutical sciences,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1995,
Naunyn-Schmiedeberg's archives of pharmacology,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
September 1985,
The Journal of pharmacology and experimental therapeutics,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1997,
Archives of gerontology and geriatrics,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
November 1993,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
November 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
L K Webster, and
D B Jones, and
G W Mihaly, and
R A Smallwood
January 1987,
Biochemical pharmacology,
