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The aim of this work was to assess the usefulness of somatostatin in acute peptic ulcer bleeding. Sixty-four patients with endoscopic evidence of duodenal ulcer bleeding completed a double-blind trial to compare the effectiveness of somatostain (6 mg i.v. per day) with that of placebo; incidence of treatment failure (i.e., rebleeding or persistent haemorrhage) was not different in the somatostatin and in the placebo groups (respectively 24% and 23%). Because the efficacy of cimetidine had previously been demonstrated in gastric ulcer bleeding, somatostatin was tested against cimetidine (1.6 g per day) in 50 patients with gastric ulcer haemorrhage. The treatment failed to control bleeding in 15% of somatostatin and in 17% of cimetidine treated subjects (n.s.). Both treatments were well tolerated and blood requirements were not different in the trial groups. These results show that the efficacy of somatostain in peptic ulcer bleeding is not different from placebo in duodenal ulcers and not different from cimetidine in gastric ulcers.
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
July 1980,
Lancet (London, England),
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
October 1980,
Lancet (London, England),
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
September 1989,
Gastroenterology,
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
October 1985,
British medical journal (Clinical research ed.),
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
November 1985,
British medical journal (Clinical research ed.),
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
November 1970,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
October 1978,
Gastroenterologie clinique et biologique,
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
September 1986,
The Australian and New Zealand journal of surgery,
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
April 1980,
Lancet (London, England),
J P Galmiche, and
J Cassigneul, and
J Faivre, and
J L Tranvouez, and
D Ouvry, and
R Colin, and
J P Pascal, and
C Klepping
May 1985,
Lancet (London, England),
