-transparent.png){kind=logo}
A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0.18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0.5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD.
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
October 1988,
Medicina clinica,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
January 1986,
Haematologica,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
June 1994,
Bone marrow transplantation,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
November 1986,
British journal of haematology,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
December 1987,
Bone marrow transplantation,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
March 1998,
Diseases of the colon and rectum,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
December 2003,
Rheumatology (Oxford, England),
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
January 1985,
Advances in experimental medicine and biology,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
February 1991,
Clinical and experimental immunology,
H Waldmann, and
A Polliak, and
G Hale, and
R Or, and
G Cividalli, and
L Weiss, and
Z Weshler, and
S Samuel, and
D Manor, and
C Brautbar
October 1985,
Schweizerische medizinische Wochenschrift,
