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Livers from rats fed the carcinogen 2-acetylaminofluorene (AAF) were analyzed at weekly or semiweekly intervals to correlate appearance of enzymatic markers in total liver homogenates with histochemical events accompanying formation of hyperplastic liver nodules. gamma-Glutamyltranspeptidase (gamma-GT)-positive foci appeared by day 11 and visible nodules were present by days 28-35. Specific activity of homogenate gamma-GT increased in parallel to formation of hyperplastic foci and nodules, declined and then rose again to 20-fold that of controls by day 77. Specific activity of ornithine decarboxylase increased in advance of that of gamma-GT, to a level of 8-fold above control during the period of formation of hyperplastic foci. An early response was a 2-fold rise in the specific activity of nucleoside diphosphate phosphatase during the first week of carcinogen administration. The specific activity of 5'-nucleotidase, known to increase during liver regeneration, declined as the animals aged and was not increased by the dietary AAF. The enzymatic alterations induced by AAF could not be mimicked by cell proliferation, diet stress or the hepatotoxicity induced by feeding 1.87% 4-acetamidophenol.
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
December 1974,
Biochemical pharmacology,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
January 1994,
Carcinogenesis,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
October 1978,
Archives internationales de physiologie et de biochimie,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
April 1991,
Gastroenterologia Japonica,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
March 2008,
Carcinogenesis,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
March 1995,
Carcinogenesis,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
April 1998,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
October 1979,
Proceedings of the National Academy of Sciences of the United States of America,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
October 2007,
Human & experimental toxicology,
W L Elliott, and
D P Sawick, and
K E Creek, and
S L Deutscher, and
J F Quinn, and
E Yeo, and
W R Webb, and
D M Morré, and
D D Harrington, and
P F Heinstein
June 1969,
European journal of cancer,
