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Analgesic poisoning is a common medical emergency, and these drugs account for about 30% of self-poisoning in adults. Aspirin and paracetamol are taken most often, and can cause significant morbidity and mortality. However, problems with the hepatotoxicity of paracetamol have been greatly reduced by the introduction of effective treatment with agents such as N-acetylcysteine. The non-steroidal anti-inflammatory analgesics are not commonly taken in overdosage but the incidence of self-poisoning with mefenamic acid is increasing at an alarming rate. With the exception of phenylbutazone and mefenamic acid these drugs rarely seem to cause serious toxicity. The narcotic analgesics can cause profound respiratory depression and are the most dangerous drugs in overdosage.
L F Prescott
September 1986,
Clinical pharmacy,
L F Prescott
January 1988,
Medical toxicology and adverse drug experience,
L F Prescott
November 1974,
Anaesthesia and intensive care,
L F Prescott
February 1969,
German medical monthly,
L F Prescott
January 1987,
Human toxicology,
L F Prescott
April 1999,
Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association,
L F Prescott
January 1989,
Medical toxicology and adverse drug experience,
L F Prescott
May 2004,
Annals of emergency medicine,
L F Prescott
January 1989,
Medical toxicology and adverse drug experience,
L F Prescott
January 1987,
Medical toxicology and adverse drug experience,
