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An in vitro study was made of the influence of the atypical neuroleptics sulpiride and carbidine on the activity of synaptosomal tyrosine hydroxylase (TH) of the rat brain striatum. Dopamine was applied as an inhibitor of tyrosine hydroxylation (10(-6) M), dopamine uptake was blocked by nomifensine (10(-5) M). The experiments were performed in two versions: in a medium containing common (5 mM) and depolarizing concentration of potassium ions. In both the cases sulpiride did not exert any noticeable effect on TH activity but significantly lowered the inhibitory action of dopamine. In a medium containing 30 mM potassium, carbidise inhibited the rate of TH hydroxylation and enhanced the inhibitory action of dopamine on TH activity under blockade of its uptake by nomifensine. It is assumed that the mechanisms of the action of carbidine and sulpiride are different.
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
September 1974,
The Journal of pharmacy and pharmacology,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
January 1978,
Annali dell'Istituto superiore di sanita,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
July 1992,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
April 1976,
Diseases of the nervous system,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
December 1987,
Brain research bulletin,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
January 1976,
Biulleten' eksperimental'noi biologii i meditsiny,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
September 1990,
Brain research,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
July 1995,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
January 1987,
Farmakologiia i toksikologiia,
A A Meos, and
V S Kudrin, and
K S Raevskiĭ
May 1979,
Life sciences,
