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Fibroblast cell lines were established from pulmonary explants derived from inbred CBA T6T6 mouse embryos. Cell lines controlled for the absence of spontaneous transformation were treated with 20=methylcholenthrene (0, 1 microgram/ml). The altered biological characteristics were studied during the process of the malignant transformation by the comparison of the untreated and 20-methylcholanthrene pretreated cell populations: the loss of contact inhibition and the connection between the malignant transformation and the arylhydrocarbon hydroxylase enzyme activity were investigated. No changes in the cell proliferation rate could be found following malignant transformation, but an increased resistance against altered circumstances was observed. In the course of passages, a gradual decreases in aryl hydrocarbon hydroxylase activity of the untreated line was seen, which disappeared or significantly decreased following 20-methylcholanthrene treatment, compared to the controls.
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
June 1972,
Indian journal of cancer,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
January 1981,
Advances in experimental medicine and biology,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
January 1995,
Polish journal of pharmacology,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
March 2017,
Naunyn-Schmiedeberg's archives of pharmacology,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
January 1983,
Cytobios,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
December 2014,
Toxicology in vitro : an international journal published in association with BIBRA,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
June 1972,
Journal of radiation research,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
August 1973,
Experimental cell research,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
January 1994,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
K Lapis, and
G Ferencz, and
B Szende, and
I Kovalszky, and
A Jeney
July 1966,
The Indian journal of medical research,
