[Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. 1980

S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva

Conditions of interferon production stimulation were studied in human tonsillar cell cultures exposed to natural and synthetic inducers : poly(I) . poly(C), phage f2 RNA replicase, phytohemagglutinin and the low-molecular inducer gossypol (beta-aminoethyl sulfoxide Na). It has been shown that being inferior in the productivity per one cell to the continuous lymphoblastoid Raji and Namalva cell liness the tonsillar cell cultures, due to their high density, produce rather high interferon titers reaching hundreds of IU50/ml. The viability of the tonsillar cell cultures and their incubation at 37 degrees C during 24 hours are rather important for adequate interferon production.

UI MeSH Term Description Entries
D007369 Interferon Inducers Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. Inducers, Interferon
D007372 Interferons Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. Interferon
D008970 Molecular Weight The sum of the weight of all the atoms in a molecule. Molecular Weights,Weight, Molecular,Weights, Molecular
D010835 Phytohemagglutinins Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture. Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D011070 Poly I-C Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid. Poly(I-C),Poly(rI).Poly(rC),Polyinosinic-Polycytidylic Acid,Polyinosinic-Polycytidylic Acid (High MW),Polyriboinosinic-Polyribocytidylic Acid,Polyribose Inosin-Cytidil,Inosin-Cytidil, Polyribose,Poly I C,Polyinosinic Polycytidylic Acid,Polyriboinosinic Polyribocytidylic Acid,Polyribose Inosin Cytidil
D002051 Burkitt Lymphoma A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative. African Lymphoma,Burkitt Cell Leukemia,Burkitt Tumor,Lymphoma, Burkitt,Burkitt Leukemia,Burkitt's Leukemia,Burkitt's Lymphoma,Burkitt's Tumor,Leukemia, Lymphoblastic, Burkitt-Type,Leukemia, Lymphocytic, L3,Lymphocytic Leukemia, L3,Burkitts Leukemia,Burkitts Lymphoma,Burkitts Tumor,L3 Lymphocytic Leukemia,L3 Lymphocytic Leukemias,Leukemia, Burkitt,Leukemia, Burkitt Cell,Leukemia, Burkitt's,Leukemia, L3 Lymphocytic,Lymphoma, African,Lymphoma, Burkitt's,Tumor, Burkitt,Tumor, Burkitt's
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003637 DEAE-Dextran Used as a support for ion-exchange chromatography. DEAE Sephadex,Diethylaminoethyldextran,Pulsar,DEAE Dextran,Sephadex, DEAE

Related Publications

S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
January 1977, Texas reports on biology and medicine,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
January 2009, Current pharmaceutical design,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
January 1992, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
January 1974, Topics in current chemistry,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
September 1983, Ceskoslovenska farmacie,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
January 1983, American journal of otolaryngology,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
July 1972, Canadian journal of comparative medicine : Revue canadienne de medecine comparee,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
June 1977, Acta pathologica et microbiologica Scandinavica. Section B, Microbiology,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
April 1977, Clinical and experimental immunology,
S S Labzo, and A S Novokhatskiĭ, and Sh K Kabirov, and V F Kniazeva
April 1976, Acta virologica,
Copied contents to your clipboard!