Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity. 1980

T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita

Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth of Micromonospora chalcea KY11091 through various procedures. Tetrocarcins showed marked activity against experimental tumors such as mouse sarcoma 180 and mouse leukemia P388. Multiple injections showed better therapeutic effect against tumors. Mode of action of tetrocarcin A against Bacillus subtilis was found to be through the inhibition of RNA synthesis.

UI MeSH Term Description Entries
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D007941 Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene. P388D(1) Leukemia,P388, Leukemia
D008297 Male Males
D002627 Chemistry, Physical The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes. Physical Chemistry,Chemistries, Physical,Physical Chemistries
D004269 DNA, Bacterial Deoxyribonucleic acid that makes up the genetic material of bacteria. Bacterial DNA
D006027 Glycosides Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed) Glycoside
D000617 Aminoglycosides Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS. Aminoglycoside
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic

Related Publications

T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
September 1980, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
August 1982, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
July 1985, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
February 1980, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
May 1985, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
June 1986, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
January 1986, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
October 1993, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
December 1981, The Journal of antibiotics,
T Tamaoki, and M Kasai, and K Shirahata, and S Ohkubo, and M Morimoto, and K Mineura, and S Ishii, and F Tomita
January 1992, Japanese journal of cancer research : Gann,
Copied contents to your clipboard!