-transparent.png){kind=logo}
The effects of substance P on anterior pituitary secretion were studied in 3 female rhesus monkeys. In nine experiments, 100 microgram substance P was injected intraventricularly, and the results were compared to those obtained following intraventricular injection of the control vehicle. In 7 out of 9 experiments, substance P induced a significant increase in prolactin secretion within 5 min. Peak levels at 10 min were approximately 15-20 times those of the baseline control. Substance P also induced a slight but significant decrease in GH secretion 20 min following injection, but at other times GH levels were not significantly changed. LH and FSH as well as cortisol concentrations remained unaltered. In 2 monkeys a decrease in systolic pressure of 40-70 mm Hg within 10-60 sec and lasting 180-300 sec was observed following the administration of substance P but not the control vehicle. The results indicate that substance P, which in the monkey has been shown to be associated with hypothalamic regions implicated in the control of anterior pituitary secretion, can alter prolactin and GH release.
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
September 1980,
Endocrinology,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
December 1990,
The Journal of clinical endocrinology and metabolism,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
March 1984,
The Journal of comparative neurology,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
January 1990,
International archives of allergy and applied immunology,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
July 1979,
Journal of steroid biochemistry,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
February 1999,
Danish medical bulletin,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
November 1982,
Endocrinology,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
August 1992,
Endocrinology,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
September 1977,
Cell and tissue research,
N Eckstein, and
W B Wehrenberg, and
K Louis, and
P W Carmel, and
E A Zimmermann, and
A G Frantz, and
M Ferin
December 1989,
Journal of neuroendocrinology,
