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Rabbits were hyperimmunized with Micrococcus Pysodeicticus, leading to homogeneous antibody responses. Peripheral blood lymphocytes were taken from the rabbits before and monthly (during 3 months) after the start of the immunization. The cells were stored frozen. Lymphocytes were tested with anti-idiotypic conjugates for the presence of surface idiotypic structures. The nature of the idiotype-positive cells was determined with respect to the presence of IgM or T-cell antigenic determinants on their surface. A sharp rise and fall in the percentage of idiotypic lymphocytes was found, ranging between 1/40,000 and 1/1,000. Initially almost all idiotypic lymphocytes were IgM-positive. In the blood taken 2 months after the start of the immunization 20% of the idiotypic cells belonged to the T-cell population and 10% were negative for both IgM and T-cell antigenic determinants.
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
October 1951,
Journal of immunology (Baltimore, Md. : 1950),
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
January 1966,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
January 1977,
Immunological reviews,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
January 1968,
Journal of immunology (Baltimore, Md. : 1950),
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
February 1965,
The Journal of experimental medicine,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
March 1967,
Experientia,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
December 1973,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
July 1978,
European journal of immunology,
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
September 1978,
Journal of immunology (Baltimore, Md. : 1950),
E J Bast, and
M Wikler, and
R Manten-Slingerland, and
H J Schuurman, and
R E Ballieux
January 1967,
Biochimica et biophysica acta,
