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The effect of an intravenous dose of mexiletine, a new anti-arrhythmic agent, on the electrophysiological properties of the intact human heart was studied in ten subjects with no evidence of cardiovascular disease. Mexiletine produced no significant changes in the sinus node recovery time, the corrected sinus node recovery time or in the atrial, atrio-ventricular and ventricular effective refractory periods. In addition mexiletine had no significant effect on proximal atrioventricular conduction. The drug did, however, prolong atrio-ventricular conduction distal to the bundle of His in all ten subjects by an average of 6 msec. This change was statistically significant (P less than 0.01). The drug is recommended to be used with caution in patients with conduction disturbances.
R W Harper, and
S B Olsson, and
E Varnauskas
January 2005,
Mikrobiologiia,
R W Harper, and
S B Olsson, and
E Varnauskas
January 1985,
International journal of clinical pharmacology research,
R W Harper, and
S B Olsson, and
E Varnauskas
June 1989,
Kokyu to junkan. Respiration & circulation,
R W Harper, and
S B Olsson, and
E Varnauskas
January 2008,
Mikrobiologiia,
R W Harper, and
S B Olsson, and
E Varnauskas
August 2012,
Langmuir : the ACS journal of surfaces and colloids,
R W Harper, and
S B Olsson, and
E Varnauskas
May 1987,
Circulation,
R W Harper, and
S B Olsson, and
E Varnauskas
February 2005,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
R W Harper, and
S B Olsson, and
E Varnauskas
December 2020,
Molecules (Basel, Switzerland),
R W Harper, and
S B Olsson, and
E Varnauskas
May 1982,
Der Internist,
R W Harper, and
S B Olsson, and
E Varnauskas
October 1980,
Annals of internal medicine,
