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Pharmacokinetic studies after a single oral dose of 750 mg of PA in 10 normal subjects were performed. In 6 of them, pharmacokinetics of NAPA were also determined after a single oral dose of 900 mg of NAPA. Substantial differences in pharmacokinetic parameters of PA depending on acetylation phenotype were found. In fast acetylators (sulphadimidine phenotyping), half-life was shorter (2.4 +/- 0.7 hr) and 24 hr urine NAPA excretion was larger (22.5 +/- 5.8% of dose) than in slow acetylators (3.6 +/- 1.0 hr and 8.8 +/- 5.4% respectively). NAPA was characterized by different pharmacokinetic parameters (t 1/2 7.0 +/- 1.0 hr, 24 hr urine elimination - 58.5% of dose). Clinical implications of these findings are discussed.
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
July 1988,
Angiology,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
January 1981,
Therapeutic drug monitoring,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
March 1981,
Journal of pharmaceutical sciences,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
June 1974,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
September 1980,
The American journal of cardiology,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
January 1984,
Kardiologia polska,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
June 1996,
Journal of pharmaceutical sciences,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
January 1978,
European journal of pharmacology,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
December 1977,
Kidney international,
M Wierzchowiecki, and
D Michałowska, and
Z Lowicki, and
R Ochotny, and
A Grześkowiak, and
T Tomaszkiewicz
October 1988,
Clinical pharmacology and therapeutics,
