Biomaterial Database

Amylase producing lung cancer. Electronmicroscopical and biochemical studies. 1980

T Morohoshi, and N Nakamura, and K Hayashi, and M Kanda

A case of the lung cancer associated with marked elevation of serum (7820 IU/1) and of urinary amylase (2225 IU/1) was autopsied. Material was examined histopathologically, electronmicroscopically and biochemically. The pulmonary tumor tissues showed histological pattern of papillary adenocarcinoma. In addition to the small round bodies which were very similar to secretory granules, many large round bodies were noticed, diffusely distributed in the tumor cell. These large round bodies ranged from 0.2 to 0.7 micrometers in diameter and showed a lamellar or annular pattern. The soluble phase of the homogenized pulmonary tumor tissues had an amylase level of 11,300 IU/g of protein, which consisted of S-type isoamylase with minor components. Cholesterol, triglyceride and phospholipid were also present at greater concentration in the tumor tissue than the normal pulmonary tissue. The large round bodies appeared too, to be amylase including bodies from the electronmicroscopical and biochemical findings.

UI	MeSH Term	Description	Entries
D008175	Lung Neoplasms	Tumors or cancer of the LUNG.	Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008297	Male		Males
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000681	Amylases	A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.	Diastase,Amylase