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The role of thymus cells in mediating a step in the ontogeny of the capacity of the B cell population to produce a heterogeneous, high-affinity, primary, plaque-forming cell (PFC) response was further investigated. It was shown that the thymus acquires the capacity to facilitate this step in B cell differentiation between 3 and 4 weeks of age in C57BL/6 mice. This corresponds to the age at which te splenic B cell population of these mice naturally acquires the capacity to produce high-affinity PFC. The differentiation of the B cell population. It was further shown that regulates this step in the cells to facilitate the maturation of B cell population. It was further shown that the ability of thymus cells to facilitate the maturation of the B cell population decreases with age and is already markedly reduced in 30-week-old, long-lived, C57BL/6 mice. A qualitative or quantitative decrease in thymic function may thus be responsible for age-related changes in the function of the B cell population.
M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
May 1978,
European journal of immunology,
M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
January 1978,
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M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
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M R Szewczuk, and
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G W Siskind
March 1991,
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M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
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M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
May 1981,
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M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
September 1984,
Journal of immunology (Baltimore, Md. : 1950),
M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
April 1983,
Cellular immunology,
M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
October 1971,
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M R Szewczuk, and
R H DeKruyff, and
E A Goidl, and
M E Weksler, and
G W Siskind
November 1974,
The Journal of experimental medicine,
