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The genetic effects of MNNG, 4NQO and ICR-170 have been compared on 5 different UV-sensitive strains and a standard wild-type strain of Neurospora crassa with regard to inactivation and the induction of forward-mutations at the ad-3A and ad-3B loci. Whereas all UV-sensitive strains (upr-1, uvs-2, uvs-3, uvs-5 and uvs-6) are more sensitive to inactivation by MNNG and ICR-170 than wild-type, only uvs-5 shows survival comparable to wild-type after 4NQO treatment, all other strains are more sensitive to 4NQO. In contrast to the effects on inactivation, a wide variety of effects were found for the induction of ad-3A and ad-3B mutations: higher forward-mutation frequencies than were found in wild-type were obtained after treatment with MNNG or 4NQO for upr-1 and uvs-2, no significant increase over the spontaneous mutation frequency was found with uvs-3 after MNNG, 4NQO or ICR-170 treatment; mutation frequencies comparable to that found in wild-type were obtained with uvs-6 after MNNG, 4NQO or ICR-170 treatment and with upr-1 after ICR-170 treatment. Lower forward-mutation frequencies than were found in wild-type were obtained with uvs-2 after ICR-170 treatment and with uvs-5 after MNNG, 4NQO or ICR-170 treatment. These data clearly show that the process of forward-mutation at the ad-3A and ad-3B loci is under genetic control by mutations at other loci (e.g. upr-1, uvs-2, uvs-3, uvs-5 and uvs-6) and that the effect is markedly mutagen-dependent.
H Inoue, and
T M Ong, and
F J de Serres
July 1980,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
March 1981,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
November 1981,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
June 1980,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
March 1983,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
January 1969,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
January 1968,
Mutation research,
H Inoue, and
T M Ong, and
F J de Serres
January 1968,
Genetics,
H Inoue, and
T M Ong, and
F J de Serres
January 1973,
Radiation research,
H Inoue, and
T M Ong, and
F J de Serres
January 1985,
Mutation research,
