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A non-filtering isolated perfused rat kidney model was developed to determine renal oxygen consumption in the absence of tubular reabsorption. The oxygen consumption in the absence of filtration was 3.1 +/- 0.8 micron of O2/min/g. This "basal" value was substantially higher than that of 2.0 micron of O2/min/g calculated by extrapolation of a plot of sodium reabsorption vs. oxygen consumption in filtering kidneys. It was also found that ouabain 10(-4) M decreased oxygen consumption in non-filtering kidneys and acetazolamide increased it in a dose dependent fashion. Furosemide did not change "basal" oxygen consumption. In filtering kidneys, the ratio of sodium reabsorbed to oxygen consumed averaged 36.8 muEq of Na/mumole of O2. It is concluded that basal oxygen consumption is not a fixed quantity and can be changed by experimental manipulations thereby changing the relation between transport activity and oxygen consumption.
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
January 1983,
Renal physiology,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
January 1964,
Scandinavian journal of clinical and laboratory investigation,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
January 1978,
Nephron,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
March 1961,
Biochimica et biophysica acta,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
January 1975,
Current problems in clinical biochemistry,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
June 1961,
Nature,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
June 1976,
Life sciences,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
June 1972,
The American journal of physiology,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
January 1969,
Bibliotheca haematologica,
R D Swartz, and
P Silva, and
R Hallac, and
F H Epstein
September 1967,
Bollettino della Societa italiana di biologia sperimentale,
