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Bacterial plasmids containing human leukocyte interferon sequences were constructed and identified. Identification was confirmed by correspondence of the nucleotide sequence with out amino acid sequence of human leukocyte interferon. The finding of bacterial recombinants containing distinct leukocyte interferon sequences is consistent with our purification of different leukocyte interferon species. We conclude that what has been designated human leukocyte interferon is, indeed, a class of homologous proteins. Preliminary indications suggest that their diversity appears to be represented by individual genomic equivalents. Each of the individual species exhibits characteristic activities. The structural modulation of these biological activities has immense significance for understanding the natural role of the interferons and for refining and developing their ultimate therapeutic potential.
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
April 1982,
Journal of molecular biology,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
June 1980,
Gene,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
March 1983,
Gene,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
January 1981,
Nucleic acids research,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
January 1981,
Texas reports on biology and medicine,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
December 1988,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
June 1981,
Nucleic acids research,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
October 1981,
Proceedings of the National Academy of Sciences of the United States of America,
S Maeda, and
R McCandliss, and
M Gross, and
A Sloma, and
P C Familletti, and
J M Tabor, and
M Evinger, and
W P Levy, and
S Pestka
February 1981,
Nucleic acids research,
