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Antigen-specific suppressor factor could be released from monkey suppressor T cells induced in vitro with a protein antigen isolated from the carcinogenic bacterium Streptococcus mutans. The suppressor activity was due to the factor itself and not to carryover of free antigen. Characterization of the monkey factor revealed it to have a molecular weight of ca. 70,000, and to contain a constant region and determinants encoded by the major histocompatibility complex. The presence of immunoglobulin determinants could not be demonstrated. However, by virtue of its adsorption to specific antigen, an antigen-combining site was shown to be present. The possible regulatory role of streptococcal antigen-specific suppressor factor in protection against dental caries is discussed.
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
December 1981,
Arerugi = [Allergy],
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
February 1981,
Journal of immunology (Baltimore, Md. : 1950),
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
December 1983,
The Journal of experimental medicine,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
January 1982,
Annales d'immunologie,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
January 1986,
Microbiology and immunology,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
August 1978,
Nature,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
February 1983,
Infection and immunity,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
January 1984,
Microbiology and immunology,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
January 1989,
International archives of allergy and applied immunology,
J R Lamb, and
E D Zanders, and
S Kontiainen, and
T Lehner
June 1982,
Proceedings of the National Academy of Sciences of the United States of America,
