Numerous drugs may cause changes in the serum concentrations of T4 and of T3. If such alterations are not recognized an incorrect diagnosis may result. In moderate degrees of hypo- and hyperthyroidism thyroid hormone levels may be spuriously normal, or the influence of pharmacological substances may lead to false diagnosis of thyroid disease in euthyroid patients. Since prediction of such alterations remains uncertain, it may be necessary to perform additional investigations when a potential artefact is recognized. On the other hand many pharmacological agents, especially those which interact with neurotransmitters, may influence TSH secretion, too. The TRH-test may show an increase or decreased TSH response, although complete suppression is only rarely seen during high-dose glucocorticoid treatment when low TRH doses are applied. Because of TRH-test gives such wide separation between different clinical states false interpretations are generally less likely than with drug-induced changes in T4 and T3 values.