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Twenty-six patients with advanced head and neck cancer, 22 of whom had failed prior surgery and/or radiotherapy, were treated with a combination regimen of cis-diamminedichloroplatinum II, bleomycin, and methotrexate. There were no complete responses. Nine patients achieved a partial response (35%). Three of the four (75%) patients without prior therapy achieved a partial response while only 6 of the 22 patients (27%) with prior surgery and/or radiation therapy obtained a partial response. The median response duration was 3 months. Patients with a partial response did not live significantly longer than those who did not live significantly longer than those who did not respond. Toxic reactions were frequent: there were three episodes of sepsis secondary to leukopenia and two cases of bleomycin pulmonary toxicity. Mucositis was noted in 40% and nausea and vomiting in 60% of patients. We conclude that this triple-drug regimen has little value in the treatment of patients with advanced squamous cell carcinoma of the head and neck who have failed prior surgery and radiotherapy.
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
December 1989,
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D D Von Hoff, and
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S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
January 1979,
Cancer treatment reports,
D D Von Hoff, and
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January 1987,
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D D Von Hoff, and
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S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
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November 1987,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
October 1984,
Cancer,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
June 1983,
Cancer treatment reports,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
January 1985,
The Netherlands journal of medicine,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
September 1985,
Cancer treatment reports,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
September 1987,
Cancer,
D D Von Hoff, and
D S Alberts, and
D E Mattox, and
S Coulthard, and
B Dana, and
M Manning, and
J W Myers, and
C B Griffin
May 1985,
Cancer,
