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The release in dog plasma of bradykinin in an experimental model in vitro and in vivo secondary to the addition of increasing amounts of trypsin was studied. The release was correlated with the degree of saturation of the plasma protease inhibitors, alpha 2-macroglobulin and alpha 1-antitrypsin, without and in the presence of Trasylol. There was a good correlation between the saturation of alpha 2-macroglobulin with trypsin and the release of bradykinin. A simultaneous fall in blood pressure was seen in the in vivo experiments. alpha 1-Antitrypsin was unable to block this tryptic activity in the absence of free alpha 2-macroglobulin. In the presence of Trasylol, the saturation of alpha 2-macroglobulin was not followed by any significant kinin liberation and the blood pressure remained stable.
G Balldin, and
E L Gustafsson, and
K Ohlsson
September 1983,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
G Balldin, and
E L Gustafsson, and
K Ohlsson
June 1978,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
G Balldin, and
E L Gustafsson, and
K Ohlsson
October 1971,
Scandinavian journal of clinical and laboratory investigation,
G Balldin, and
E L Gustafsson, and
K Ohlsson
December 1982,
Biochimica et biophysica acta,
G Balldin, and
E L Gustafsson, and
K Ohlsson
January 1990,
Haemostasis,
G Balldin, and
E L Gustafsson, and
K Ohlsson
July 1967,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
G Balldin, and
E L Gustafsson, and
K Ohlsson
April 1988,
Scandinavian journal of clinical and laboratory investigation,
G Balldin, and
E L Gustafsson, and
K Ohlsson
May 1979,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
G Balldin, and
E L Gustafsson, and
K Ohlsson
April 1957,
Archives internationales de pharmacodynamie et de therapie,
G Balldin, and
E L Gustafsson, and
K Ohlsson
August 1968,
Bollettino della Societa italiana di biologia sperimentale,
