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Twenty patients with chronic active hepatitis and 12 patients with chronic persistent hepatitis associated with hepatitis B virus (HBV) infection were treated with human leukocyte interferon or adenine arabinoside alone or in combination. With interferon alone, four of 16 patients showed a permanent disappearance of HBV-associated DNA polymerase (DNAP) activity from serum. Of six patients treated with adenine arabinoside alone, only one patient became permanently DNAP-negative. With a regimen of multiple cycles of combined interferon and adenine arabinoside, seven of 16 male patients became permanently DNAP-negative. Of 69 patients who met the criteria for admission to the program, spontaneous decreases in DNAP activity without treatment were observed in only 9% during a mean observation period of 10 months. In general, patients with chronic active hepatitis, those who are female, and those with a history of recent steroid therapy responded to the antiviral agents significantly better than did the other patients.
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
January 1981,
Hepatology (Baltimore, Md.),
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
July 1984,
The Journal of antimicrobial chemotherapy,
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
March 1983,
Presse medicale (Paris, France : 1983),
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
December 1979,
Antimicrobial agents and chemotherapy,
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
April 1986,
British medical journal (Clinical research ed.),
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
October 1986,
British medical journal (Clinical research ed.),
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
February 1977,
Antimicrobial agents and chemotherapy,
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
January 1986,
Journal of hepatology,
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
December 1984,
Journal of the Royal Society of Medicine,
G H Scullard, and
R B Pollard, and
J L Smith, and
S L Sacks, and
P B Gregory, and
W S Robinson, and
T C Merigan
February 1988,
American journal of clinical pathology,
