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Hepatoma tissue culture cells, grown in the presence of D-galactosamine and 6-azauridine, demonstrate a strong reduction of the intracellular UTP pool that can be replenished by formation of UTP from uridine and FUTP from 5-fluorouridine within 2 h. Concomitantly with the UTP deficiency, a decrease of dexamethasone-induced tyrosine aminotransferase activity occurs. 5-Fluorouridine, as compared to uridine, is even more efficient in restoring the activity of tyrosine aminotransferase. Treatment of the cells with D-galactosamine alone results in a minor lowering of UTP that is not followed by the inhibition of the enzyme induction. However, the administration of D-galactosamine, simultaneously or at any time up to 5 h before or after dexamethasone, leads to a 1.5- to 2-fold higher induction (superinduction) which appears 24 h later.
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
February 1983,
The Japanese journal of experimental medicine,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
June 1975,
Proceedings of the National Academy of Sciences of the United States of America,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
October 1981,
Journal of biochemistry,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
April 1975,
Biochemical and biophysical research communications,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
January 1979,
Monographs on endocrinology,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
June 1977,
The Journal of biological chemistry,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
May 1979,
Cell biology international reports,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
January 1973,
The Journal of biological chemistry,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
January 1969,
Proceedings of the National Academy of Sciences of the United States of America,
E M Giesen, and
G Beck, and
A Holstege, and
D O Keppler
November 1975,
Cancer research,
