BIOMAT Database Logo BIOMAT Database Logo

An in vitro method to determine the sensitivity of solid malignant tumours to cytostatic agents. 1977

N P Bishun, and J Reed, and D Williams

A simple technique is described in which several human solid tumours were assessed in vitro for their sensitivity to cytostatic agents. The technique is reliable, simple, and can be used as an aid to implement chemotherapeutic regimes.

UI MeSH Term Description Entries
D008727 Methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Amethopterin,Methotrexate Hydrate,Methotrexate Sodium,Methotrexate, (D)-Isomer,Methotrexate, (DL)-Isomer,Methotrexate, Dicesium Salt,Methotrexate, Disodium Salt,Methotrexate, Sodium Salt,Mexate,Dicesium Salt Methotrexate,Hydrate, Methotrexate,Sodium, Methotrexate
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004261 DNA Replication The process by which a DNA molecule is duplicated. Autonomous Replication,Replication, Autonomous,Autonomous Replications,DNA Replications,Replication, DNA,Replications, Autonomous,Replications, DNA
D005472 Fluorouracil A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. 5-FU,5-FU Lederle,5-FU Medac,5-Fluorouracil,5-Fluorouracil-Biosyn,5-HU Hexal,5FU,Adrucil,Carac,Efudex,Efudix,Fluoro-Uracile ICN,Fluoroplex,Fluorouracil Mononitrate,Fluorouracil Monopotassium Salt,Fluorouracil Monosodium Salt,Fluorouracil Potassium Salt,Fluorouracil-GRY,Fluorouracile Dakota,Fluorouracilo Ferrer Far,Fluoruracil,Fluracedyl,Flurodex,Haemato-FU,Neofluor,Onkofluor,Ribofluor,5 FU Lederle,5 FU Medac,5 Fluorouracil,5 Fluorouracil Biosyn,5 HU Hexal,Dakota, Fluorouracile,Fluoro Uracile ICN,Fluorouracil GRY,Haemato FU
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D014750 Vincristine An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) Leurocristine,Citomid,Farmistin,Oncovin,Oncovine,Onkocristin,Vincasar,Vincasar PFS,Vincristin Bristol,Vincristin medac,Vincristine Sulfate,Vincrisul,Vintec,cellcristin,PFS, Vincasar,Sulfate, Vincristine

Related Publications

N P Bishun, and J Reed, and D Williams
[In vitro-determination of the cytostatic sensitivity of malignant tumours (author's transl)].
October 1973, Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde,
N P Bishun, and J Reed, and D Williams
[Testing of solid tumors in childhood for sensitivity against cytostatic agents using an autoradiographic in vitro method (short-term method) (author's transl)].
January 1979, Archiv fur Geschwulstforschung,
N P Bishun, and J Reed, and D Williams
[Sensitivity tests of malignant tumours against cytostatic agents in vitro and in vivo/studies on the mouse sarcoma 180 (author's transl)].
July 1975, Arzneimittel-Forschung,
N P Bishun, and J Reed, and D Williams
In vitro prediction of cytostatic drug resistance in primary cell cultures of solid malignant tumours.
January 1993, European journal of cancer (Oxford, England : 1990),
N P Bishun, and J Reed, and D Williams
[Determination of the sensitivity of leukemic blasts to cytostatic agents by means of an isotope method].
January 1981, Folia haematologica (Leipzig, Germany : 1928),
N P Bishun, and J Reed, and D Williams
In vitro sensitivity of human ovarian tumours to chemotherapeutic agents.
August 1981, British journal of cancer,
N P Bishun, and J Reed, and D Williams
[Sensitivity testing of malignant human tumors against cytostatic agents. II].
February 1972, Klinische Wochenschrift,
N P Bishun, and J Reed, and D Williams
The sensitivity testing of Wilms' tumors to cytostatic agents with an autoradiographic in vitro short-term test.
January 1984, Neoplasma,
N P Bishun, and J Reed, and D Williams
[Results of determining the sensitivity of hypernephroid cancer to cytostatic agents in vitro and clinically].
July 1977, Antibiotiki,
N P Bishun, and J Reed, and D Williams
[Study of the blast cell sensitivity to cytostatic agents in acute leukemia by the radioisotope method].
April 1980, Polski tygodnik lekarski (Warsaw, Poland : 1960),
Copied contents to your clipboard!