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No consensus about the antigenicity of monocomponent insulin has yet been reached. We have therefore administered different insulin preparations to rabbits and rats to determine IgG and IgE antibody production. The preparations used were porcine monocomponent insulin, conventional bovine and porcine insulin powders, porcine b-component and synthesized porcine mono-desamido-insulin and hexa-desamido-insulin. In rabbits, porcine b-component was the most antigenic preparation, followed by conventional bovine and porcine insulins. No antibody production was observed with the other preparations. In rats the 60 h passive cutaneous anaphylaxis test showed virtually no insulin IgE antibody production in response to porcine monocomponent insulin. However, if porcine b-component or porcine hexa-desamido-insulin was employed both for sensitisation and as the challenging antigen, positive skin reactions were observed with demonstration of insulin IgE antibodies. Our results confirm the low antigenicity of the pharmaceutical preparation of porcine monocomponent insulin and suggest that porcine hexa-desamido-insulin and porcine b-component administration may result in the production of reagin-type antibodies.
T Kasama, and
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K Namie, and
M Sugiura
April 1975,
Lancet (London, England),
T Kasama, and
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May 1974,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Kasama, and
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K Namie, and
M Sugiura
July 1975,
Diabetes,
T Kasama, and
Y Iwata, and
K Oshiro, and
M Uchida, and
Y Sakaguchi, and
K Namie, and
M Sugiura
November 1974,
Lancet (London, England),
T Kasama, and
Y Iwata, and
K Oshiro, and
M Uchida, and
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M Sugiura
October 1974,
Lancet (London, England),
T Kasama, and
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M Sugiura
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Ugeskrift for laeger,
T Kasama, and
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K Namie, and
M Sugiura
April 1976,
Nederlands tijdschrift voor geneeskunde,
T Kasama, and
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August 1985,
The Journal of the Association of Physicians of India,
T Kasama, and
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September 1978,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
T Kasama, and
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October 1980,
Orvosi hetilap,
