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Clinical trials for abatement of intractable pelvic cancer pain were conducted in two patients, each electing surgical implantation of one of two indwelling catheter systems for administration of morphine into the spinal epidural space. Both systems, one consisting of a partially indwelling Broviac catheter, and the other, completely indwelling, consisting of a morphine reservoir connected to a shunt pump and on-off Hakim valve assembly, permitted the patients to return home where they could self-administer epidural morphine. Each patient reported that 2 mg of epidural morphine provided 8 to 12 hours of pain relief at a level of superior to their previous narcotic medication. On a regimen of 2 mg of epidural morphine administered twice daily, both patients experienced analgesia for 6 months, unaccompanied by alterations in sensory, motor, or cognitive functioning, and with a little drug tolerance reaction.
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
September 1989,
The Clinical journal of pain,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
August 1987,
Anesthesia and analgesia,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
March 1987,
Cancer,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
November 1983,
International journal of clinical pharmacology, therapy, and toxicology,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
March 1986,
The American surgeon,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
October 2017,
Archivos de bronconeumologia,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
September 1984,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
April 1996,
Southern medical journal,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
October 1983,
Neurosurgery,
C E Poletti, and
A M Cohen, and
D P Todd, and
R G Ojemann, and
W H Sweet, and
N T Zervas
September 1987,
Presse medicale (Paris, France : 1983),
