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Penetration of dioxidine to the cells of Staphylococcus aureus and the drug effect on subcellular fractions were examined. High pressure liquid chromatography demonstrated that after penetration to the cells of Staphylococcus aureus dioxidine was found unchanged in the cytoplasmic fraction. Differences were disclosed in the biochemical action pattern of the drug on the growing and stationary culture. Exposure of the growing culture to dioxidine resulted in an appreciable decrease in the protein and especially in nucleic acid levels, in significant changes in the composition of the intracellular protein complex. The drug produced structural alterations within the cell wall. These alterations increased with concentrations and were characterized by the loosening of the wall and by the membrane release.
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N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
January 1984,
Farmakologiia i toksikologiia,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
January 1982,
Farmakologiia i toksikologiia,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
November 1981,
Canadian journal of physiology and pharmacology,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
August 1959,
A.M.A. archives of pathology,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
April 1971,
Experimental neurology,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
January 1993,
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I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
February 1989,
Biokhimiia (Moscow, Russia),
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
January 1986,
Nervnaia sistema,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
January 1969,
Acta physiologica latino americana,
I N Degtiareva, and
N I Fadeeva, and
L I Budanova, and
V A Kuzovkin, and
L F Stebaeva
December 1969,
The Journal of pharmacology and experimental therapeutics,
