-transparent.png){kind=logo}
1 Corticosteroids are known to suppress evoked histamine release from human skin in vitro. Therefore the effect of prednisone, on cold evoked histamine release and clinical response was studied in six patients with acquired cold urticaria. 2 Following cold challenge all six patients developed an immediate urticarial response of the forearm and elevation of histamine levels, measured by superfusion cascade bioassay of the venous blood draining the forearm. 3 After treatment with prednisone, in an oral dose of 20-25 mg for 1 to 5 days, a suppression of evoked histamine release occurred in all but one patient. However, there was no corresponding decrease of erythema or oedema, though pruritus was improved in most patients. 4 The lack of clinical improvement in erythema and oedema, despite reduction in histamine levels, suggests that histamine may not be the principal mediator of the vascular response to cold challenge in acquired cold urticaria.
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
February 1980,
Archives of dermatology,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
December 1997,
International archives of allergy and immunology,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
August 1983,
The Journal of dermatology,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
January 1992,
Annals of allergy,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
October 1978,
The Journal of investigative dermatology,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
December 2002,
Allergy,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
July 1976,
Lancet (London, England),
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
September 1986,
The Journal of allergy and clinical immunology,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
January 1983,
Dermatologische Monatschrift,
A K Black, and
T M Keahey, and
R A Eady, and
M W Greaves
January 1991,
The Journal of allergy and clinical immunology,
