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Cells of the original human myelogenous leukemia cell line, K 562 were induced to synthesize hemoglobin by incubation with 0.05 mM hemin. Analysis by isoelectric focusing indicated major bands in the region of hemoglobin F, Bart's hemoglobin, and embryonics. Cytochemical analysis by the Lepehene peroxidase reaction for hemoglobin indicated an heterogeneous population of cells with respect to hemoglobin induction. Approximately 50% of the cells were positive for hemoglobin. The benzidine-positive material was present as granules in the region of the Golgi apparatus of large blasts with undifferentiated nuclei. There was no indication of normal maturation or of terminal differentiation into reticulocytes or erythrocytes.
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
January 1982,
Birth defects original article series,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
January 1984,
Anticancer research,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
January 1979,
Leukemia research,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
March 1985,
International journal of cell cloning,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
June 1983,
Blood,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
September 1984,
Cancer research,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
April 1981,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
January 1987,
Leukemia research,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
November 1983,
Cancer research,
J E Fuhr, and
E G Bamberger, and
C B Lozzio, and
B B Lozzio
January 1985,
Archiv fur Geschwulstforschung,
