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The effects of chronic administration of three different doses of iprindole on the monoamine oxidase activity and neurotransmitter content were studied in the cerebral cortex, the mesencephalon and the cerebellum of mouse brain. The treatment inhibited mitochondrial monoamine oxidase activity of all three brain regions studied, although a dose-response inhibitory effect was found only in the mesencephalon. Brain regional serotonin contents were markedly increased after iprindole treatment. The 5-hydroxyindoleacetic acid contents showed a significant decrease only in the cerebral cortex. Neither dopamine nor norepinephrine brain regional contents were significantly altered. On the basis of these results it is suggested that a substrate-specific inhibition of monoamine oxidase is involved in the mechanism of action of this tricyclic antidepressant.
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
April 1977,
Psychopharmacology,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
June 1980,
Biological psychiatry,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
January 1975,
Biochemical pharmacology,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
April 2014,
Journal of neural transmission (Vienna, Austria : 1996),
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
December 1993,
Alcoholism, clinical and experimental research,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
January 1984,
Progress in neuro-psychopharmacology & biological psychiatry,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
July 1987,
The Indian journal of medical research,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
April 1978,
Psychopharmacology,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
February 1979,
Vrachebnoe delo,
B G Ortega-Corona, and
J Carranza, and
A Sosa, and
P Guzmán-Amaya, and
N S Esparza-Avalos, and
G Castro-Osuna
January 1980,
Life sciences,
