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From January 1975 to December 1979, 14 consecutive patients with advanced (stage III-IV) diffuse lymphocytic, poorly differentiated lymphoma (DLPD) were treated with adriamycin, bleomycin, vinblastine and DTIC (ABVD). Either maintenance combination chemotherapy with CVP or radiotherapy over bulky disease was added in the cases with complete response (CR). Fifty per cent of the patients achieved CR and 80% achieved objective responses. Among CRs, 100% were alive at 2 years, 70% of them without evidence of disease. Overall, 75% of the patients were alive at 2 years, 30% without evidence of disease. Toxicity was acceptable and no drug-related deaths occurred. ABVD is not the ideal combination for DLPD, but it should be taken into consideration in patients with advanced DLPD in which first line combination chemotherapy regimens are not successful.
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
May 1978,
Cancer,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
June 1984,
Cancer,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
August 1979,
Cancer research,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
December 1992,
Missouri medicine,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
February 1986,
Medicina clinica,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
January 1981,
Cancer treatment reports,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
July 1976,
Cancer treatment reports,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
August 1984,
Blood,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
October 1976,
Annals of internal medicine,
E Grigoletto, and
U Tirelli, and
S Tumolo, and
E Galligioni, and
A Veronesi, and
M G Trovò, and
G Franchin, and
A De Paoli, and
R Volpe, and
A Carbone
October 1978,
Cancer,
