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Human T lymphocytes precultured for 36 hr in the presence of soluble HLA-DR antigens suppress the MLR response of autologous peripheral blood lymphocytes to allogeneic stimulating cells. The suppression is DR antigen-specific in that it appears that the MLR stimulating cell donor and the soluble suppressor-inducing antigen must share DR specificities. The soluble DR antigens were fractionated from the sera of normal donors using QAE-Sephadex chromatography and CNBr-activated Sepharose immunoadsorption. Similarly prepared HLA-A and -B antigens failed to induce suppressive activity. The suppressive activity of DR-antigen cultured T cells is resistant to mitomycin C treatment and, further, the antigen specificity is maintained with or without mitomycin C treatment. The kinetics of suppressor cell induction as well as the kinetics of suppression in the test MLR cultures are presented. The implications of these results are discussed.
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
October 1983,
Tissue antigens,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
January 1980,
Nature,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
February 1978,
Nature,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
November 1978,
Nature,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
March 1980,
Tissue antigens,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
January 1984,
Methods in enzymology,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
November 1982,
Tissue antigens,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
November 1989,
Clinical immunology and immunopathology,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
December 1978,
Transplantation proceedings,
R S Smeraldi, and
G Fabio, and
P Bonara, and
M G Villa, and
M Vanoli, and
C Pettenati, and
C Rugarli, and
C Zanussi
August 1979,
Journal of immunology (Baltimore, Md. : 1950),
