Biomaterial Database

Effect of the pH-zero point of charge relationship on the interaction of ionic compounds and polyols with aluminum hydroxide gel. 1982

D N Shah, and J R Feldkamp, and J L White, and S L Hem

The adsorption of magnesium nitrate, docusate sodium, and mannitol by chloride-containing aluminum hydroxide gel or aluminum hydroxycarbonate gel can be directly related to the surface charge characteristics of the aluminum hydroxide gel as determined by the pH-zero point of charge (ZPC) relationship. Magnesium cation is completely adsorbed under pH conditions where the gel has a negative surface charge, i.e. when the pH is above the ZPC. Docusate sodium is more strongly adsorbed when the pH-ZPC relationship causes the surface charge of aluminum when the pH-ZPC relationship causes the surface charge of aluminum hydroxycarbonate gel to be positive indicating adsorption of the docusate anion. However, adsorption also occurred when the pH was above the ZPC suggesting that adsorption of the hydrophobic portion of docusate anion by van der Waals forces also contributes to the overall adsorption mechanism. Mannitol is adsorbed under all pH conditions. However, greater adsorption occurs when the pH is above the ZPC. Maximum hydrogen bonding is believed to occur when mannitol acts as the proton donor and the negative aluminum hydroxycarbonate gel surface serves as the proton acceptor.

UI	MeSH Term	Description	Entries
D008274	Magnesium	A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D008353	Mannitol	A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.	(L)-Mannitol,Osmitrol,Osmofundin
D009566	Nitrates	Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	Nitrate
D002626	Chemistry, Pharmaceutical	Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.	Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D004143	Dioctyl Sulfosuccinic Acid	All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.	Dioctyl Sulfosuccinates,Docusate,Aerosol OT,Colace,DEH-Na-SS,DOSS,Diethylhexyl Sodium Sulfosuccinate,Dioctyl Sulfosuccinate,Dioctyl Sulfosuccinic Acid, Ammonium Salt,Dioctyl Sulfosuccinic Acid, Barium Salt,Dioctyl Sulfosuccinic Acid, Calcium Salt,Dioctyl Sulfosuccinic Acid, Magnesium Salt,Dioctyl Sulfosuccinic Acid, Potassium Salt,Dioctyl Sulfosuccinic Acid, Sodium Salt,Dioctylsulfosuccinate,Docusate Calcium,Docusate Potassium,Docusate Sodium,Sodium Bis(2-ethylhexyl)sulfosuccinate,Sodium Dioctyl Sulfosuccinate,Sodium Dioctylsulphosuccinate,Sulfosuccinic Acid bis(2-Ethylhexyl) Ester,DEH Na SS,Dioctyl Sulfosuccinate, Sodium,Dioctylsulphosuccinate, Sodium,Sodium Sulfosuccinate, Diethylhexyl,Sulfosuccinate, Diethylhexyl Sodium,Sulfosuccinate, Dioctyl,Sulfosuccinates, Dioctyl
D004563	Electrochemistry	The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.	Electrochemistries
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000327	Adsorption	The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.	Adsorptions
D000536	Aluminum Hydroxide	A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.	Hydrated Alumina,Aldrox,Algeldrate,Alhydrogel,Alugel,Amphojel,Basalgel,Brasivil,Dialume,Nephrox,Pepsamer,Rocgel,Alumina, Hydrated,Hydroxide, Aluminum
D017616	Magnesium Compounds	Inorganic compounds that contain magnesium as an integral part of the molecule.	Compounds, Magnesium