Biomaterial Database

Behavioral investigation of neurotoxicity: the effects of colchicine, lumicolchicine and vincristine sulfate on goldfish optic nerve regeneration. 1981

R E Davis, and S Benloucif

Experiments were carried out to investigate a behavioral method of assessing neurotoxicity. The proposition is that developing or regenerating neurons. The regenerating optic nerve in goldfish was examined as a preparation for investigating the effects of chemicals on neuronal development. Restoration of optic nerve connections following crushing of the optic nerve, as detected by a noninvasive behavioral technique permitting sequential testing of individual fish, occurred within 17 days. The effect on regeneration of biweekly, intraperitoneal administration of alkaloid neurotoxins was investigated. Regeneration was inhibited by colchicine and vincristine sulfate but not by lumicolchicine. The potency of vincristine was approximately twice that of colchicine. Neither drug had a detectable effect on the maintenance of optic nerve function in sham-operated fish. The results suggest that the behavioral protocol can be used to identify chemical agents which impair neuronal development in vivo, and to estimate their relative neurotoxicity.

UI	MeSH Term	Description	Entries
D008162	Lumicolchicines	Three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actions.	beta-Lumicolchicine,gamma-Lumicolchicine,beta Lumicolchicine,gamma Lumicolchicine
D009416	Nerve Regeneration	Renewal or physiological repair of damaged nerve tissue.	Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D009900	Optic Nerve	The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.	Cranial Nerve II,Second Cranial Nerve,Nervus Opticus,Cranial Nerve, Second,Cranial Nerves, Second,Nerve, Optic,Nerve, Second Cranial,Nerves, Optic,Nerves, Second Cranial,Optic Nerves,Second Cranial Nerves
D010775	Photic Stimulation	Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.	Stimulation, Photic,Visual Stimulation,Photic Stimulations,Stimulation, Visual,Stimulations, Photic,Stimulations, Visual,Visual Stimulations
D003078	Colchicine	A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).	Colchicine, (+-)-Isomer,Colchicine, (R)-Isomer
D006054	Goldfish	Common name for Carassius auratus, a type of carp (CARPS).	Carassius auratus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001370	Axonal Transport	The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)	Axoplasmic Flow,Axoplasmic Transport,Axoplasmic Streaming,Axonal Transports,Axoplasmic Flows,Axoplasmic Transports,Streaming, Axoplasmic,Transport, Axonal,Transport, Axoplasmic,Transports, Axonal,Transports, Axoplasmic
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D014750	Vincristine	An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)	Leurocristine,Citomid,Farmistin,Oncovin,Oncovine,Onkocristin,Vincasar,Vincasar PFS,Vincristin Bristol,Vincristin medac,Vincristine Sulfate,Vincrisul,Vintec,cellcristin,PFS, Vincasar,Sulfate, Vincristine